Mild cognitive impairment (MCI) impairment is a condition in which there are some cognitive changes that are not severe enough to interfere significantly with daily life, but are greater than would be expected in ‘normal ageing’. Not all with mild cognitive impairment progress to develop a dementia. A recent systematic review (Triccoa et al, 2013) found that neither cholinesterase inhibitors or memantine improved the cognition or function in patients with mild cognitive impairment.
Tricco, A., Soobiah, C., Berliner, S., Ho, J., Ng, C., Ashoor, H., & … Straus, S. (2013). Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis. CMAJ: Canadian Medical Association Journal = Journal De L’association Medicale Canadienne, 185(16), 1393-1401. doi:10.1503/cmaj.130451